| 3.Cytogenetic damage induced by thiodicarb, a carbamate insecticide in the bone marrow of Calotes versicolor |
| Nisha Shrivastava, Anisha and Tumul Singh |
| The present work is designed to investigate in vivo cytogenetic effects of thiodicarb a carbamate insecticide, by evaluating its capability to induce clastogenic effects in the bone marrow cells of garden lizard Calotes versicolor. Adult male garden lizards were acclimatized for one week in the laboratory and then treated daily with an intraperitoneal dose of 1/4th LD50 (40mg/kg body weight) of thiodicarb. The bone marrow was used for Micronucleus Assay. The obtained data showed significant increase of MN frequency in Polychromatic Erythrocytes of the bone marrow (P≤ 0.005). This study also reveals that significant level of induction is time dependent as the significant increase in MN was seen after 21 and 28 days of treatment when compared to control. |